Services
The NRCH offers a selection of services to assist investigators with challenges related to the solution characterization of macromolecules. Rigorous analysis of macromolecular properties in the solution phase is a demanding task, extending into a wide range of scientific fields including biophysics and other life sciences, material science, colloid chemistry, physics, mathematics and computer science. We have accumulated 30+ years of expertise in these fields to offer you assistance, guidance and training.
Our services include:
- Sample Analysis: We provide custom AUC analysis of your solution samples to provide particle sizing, information about oligomerization behavior, viral vector cargo loading, lipid nanoparticle composition, small molecule binding, aggregation quantification, Kd measurements, size, shape and density distributions. We will work with your group to develop the optimal experimental design and will post all analysis results in your LIMS account. Optionally, we can provide custom reports which summarize the results from the performed experiments. We accept any materials suitable for solution characterization, including biopolymers, nanomaterials, quantum dots and synthetic polymers. Our collaborations extend worldwide, and we welcome collaborations from academia, government research labs and industry.
- Protocol Development: We can work with your team to develop systematic analysis protocols for formulation characterization, aggregation quantification, reproducibility and sameness studies.
- How to request service: All NRCH projects are managed through our online LIMS system. New users can request a LIMS account by visiting
- An e-mail will be sent to the specified address with a verification link and a temporary password for accessing the account. After confirming your account, you can log in and manage your projects here:
- Next, visit the “Change my info” link to update your password. In the next step, select the “Projects” button to create a new project. For each project, please enter a title, and enter the requested fields, except “Experimental Design”, which will be handled by our staff. Please save your work frequently. Your responses can be updated at any time.
The NRCH facility is directed by Borries Demeler. The laboratory is managed by Michelle Nemetchek and Cindee Yates-Hansen